5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE
ELLIPTICINE
CAS: 519-23-3
Molecular Formula: C17H14N2
5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE - Names and Identifiers
5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE - Physico-chemical Properties
| Molecular Formula | C17H14N2 |
| Molar Mass | 246.31 |
| Density | 1.257±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 316-318°C |
| Boling Point | 379.31°C (rough estimate) |
| Solubility | Soluble in water |
| Appearance | Bright yellow solid |
| Merck | 13,3581 |
| pKa | 16.59±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Sensitive | `sensitive` to fire and oxides |
| Refractive Index | 1.5794 (estimate) |
| MDL | MFCD00010524 |
| In vitro study | Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts. |
| In vivo study | Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795). |
5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UU8825000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten) |
5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE - Reference Information
| biological activity | elliticine (NSC 71795) is a potent antineoplastic agent that inhibits DNA topoisomerase II activity. |
Last Update：2024-04-10 22:29:15
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Product Name: ELLIPTICINE Visit Supplier Webpage Request for quotationCAS: 519-23-3
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Tel: +86-18821248368
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Product Name: ELLIPTICINE Visit Supplier Webpage Request for quotation
CAS: 519-23-3
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CAS: 519-23-3
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View History
5,11-DIMETHYLPYRIDO[4,3-B]CARBAZOLE
7,1-双(4-(二苯基氨基)苯基)-2,3-双氰基吡嗪并菲
NSC 341958
2-氯吡啶-3-甲酸乙酯
Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5α,6α)-, 6-formate (9CI)
[2H3]-7-Ethyl-10- (4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin
二喹啉羧酸二钠水合物
CCRIS 1717
N-(Trifluoroacetyl)-L-aspartic acid bis(1-methylpropyl) ester
Polyalthic acid
7,1-双(4-(二苯基氨基)苯基)-2,3-双氰基吡嗪并菲
NSC 341958
2-氯吡啶-3-甲酸乙酯
Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5α,6α)-, 6-formate (9CI)
[2H3]-7-Ethyl-10- (4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin
二喹啉羧酸二钠水合物
CCRIS 1717
N-(Trifluoroacetyl)-L-aspartic acid bis(1-methylpropyl) ester
Polyalthic acid